Journal article
Increased cancer risks for relatives of very early-onset breast cancer cases with and without BRCA1 and BRCA2 mutations
GS Dite, AS Whittemore, JA Knight, EM John, RL Milne, IL Andrulis, MC Southey, MRE McCredie, GG Giles, A Miron, AI Phipps, DW West, JL Hopper
British Journal of Cancer | NATURE PUBLISHING GROUP | Published : 2010
Abstract
Background:Little is known regarding cancer risks for relatives of women with very early-onset breast cancer.Methods:We studied 2208 parents and siblings of 504 unselected population-based Caucasian women with breast cancer diagnosed before age 35 years (103 from USA, 124 from Canada and 277 from Australia), 41 known to carry a mutation (24 in BRCA1, 16 in BRCA2 and one in both genes). Cancer-specific standardised incidence ratios (SIRs) were estimated by comparing the number of affected relatives (50% verified overall) with that expected based on incidences specific for country, sex, age and year of birth.Results:For relatives of carriers, the female breast cancer SIRs were 13.13 (95% CI 6...
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the National Cancer Institute, National Institutes of Health under RFA no. CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry (Breast CFR) and Principal Investigators, including Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), Columbia University (U01 CA69398), Northern California Cancer Center (U01 CA69417), Cancer Care Ontario (U01 CA69467) and The University of Melbourne (U01 CA69638). The Australian Breast Cancer Family Study was also supported by the National Health and Medical Research Council (NHMRC) of Australia, the New South Wales Cancer Council and the Victorian Health Promotion Foundation. The content of this paper does not necessarily reflect the views or policies of the National Cancer Institute or any of the collaborating centres in the Breast CFR, nor does mention of trade names, commercial products or organisations imply endorsement by the US Government or the Breast CFR. JLH is an Australia Fellow of the NHMRC and a Victorian Breast Cancer Research Consortium (VBCRC) Group Leader. MCS is a Research Fellow of the NHMRC and a VBCRC Group Leader. We thank the participants in the Breast CFR and the Ontario Familial Breast Cancer Registry. We also thank Gord Glendon, Hilmi Ozcelik and members of the Ontario Cancer Genetics Network for their contributions to the study.